Mitochondrial Membrane Dynamics—Functional Positioning of OPA1
نویسندگان
چکیده
منابع مشابه
Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion.
Mitochondrial fusion requires the coordinated fusion of the outer and inner membranes. Three large GTPases--OPA1 and the mitofusins Mfn1 and Mfn2--are essential for the fusion of mammalian mitochondria. OPA1 is mutated in dominant optic atrophy, a neurodegenerative disease of the optic nerve. In yeast, the OPA1 ortholog Mgm1 is required for inner membrane fusion in vitro; nevertheless, yeast la...
متن کاملMitochondrial Function: OMA1 and OPA1, the Grandmasters of Mitochondrial Health
McVean, G.A., Gabriel, S.B., Reich, D., Donnelly, P., et al. (2005). Comparison of fine-scale recombination rates in humans and chimpanzees. Science 308, 107–111. 14. Ptak, S.E., Hinds, D.A., Koehler, K., Nickel, B., Patil, N., Ballinger, D.G., Przeworski, M., Frazer, K.A., and Paabo, S. (2005). Fine-scale recombination patterns differ between chimpanzees and humans. Nat. Genet. 37, 429–434. 15...
متن کاملProteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.
Mitochondrial fusion is essential for maintenance of mitochondrial function. The mitofusin GTPases control mitochondrial outer membrane fusion, whereas the dynamin-related GTPase Opa1 mediates inner membrane fusion. We show that mitochondrial inner membrane fusion is tuned by the level of oxidative phosphorylation (OXPHOS), whereas outer membrane fusion is insensitive. Consequently, cells from ...
متن کاملOPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L
OPA1, a dynamin-related guanosine triphosphatase mutated in dominant optic atrophy, is required for the fusion of mitochondria. Proteolytic cleavage by the mitochondrial processing peptidase generates long isoforms from eight messenger RNA (mRNA) splice forms, whereas further cleavages at protease sites S1 and S2 generate short forms. Using OPA1-null cells, we developed a cellular system to stu...
متن کاملMitochondrial OPA1, apoptosis, and heart failure.
AIMS Mitochondrial fusion and fission are essential processes for preservation of normal mitochondrial function. We hypothesized that fusion proteins would be decreased in heart failure (HF), as the mitochondria in HF have been reported to be small and dysfunctional. METHODS AND RESULTS Expression of optic atrophy 1 (OPA1), a mitochondrial fusion protein, was decreased in both human and rat H...
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ژورنال
عنوان ژورنال: Antioxidants
سال: 2018
ISSN: 2076-3921
DOI: 10.3390/antiox7120186